Prior to starting any clinical research, an investigator must determine the appropriate study design to answer the question at hand. Selecting the correct study type also depends on ethical considerations, disease of interest, and the resources available. A well-designed study will clearly identify an exposure and an outcome in an objective, quantifiable manner to answer a defined hypothesis. After thorough data analysis and discussion of the results, the study will ideally prompt further research on the subject. Understanding the various indications for different study designs is important not only for devising one’s own study but also for critically reviewing the literature. This article outlines frequently encountered study designs in clinical research and their respective strengths and drawbacks.
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