
Prior to starting any clinical research, an investigator must determine
the appropriate study design to answer the question at hand. Selecting
the correct study type also depends on ethical considerations, disease
of interest, and the resources available. A well-designed study will
clearly identify an exposure and an outcome in an objective,
quantifiable manner to answer a defined hypothesis. After thorough data
analysis and discussion of the results, the study will ideally prompt
further research on the subject. Understanding the various indications
for different study designs is important not only for devising one’s own
study but also for critically reviewing the literature. This article
outlines frequently encountered study designs in clinical research and
their respective strengths and drawbacks.
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