
 Prior to starting any clinical research, an investigator must determine 
the appropriate study design to answer the question at hand. Selecting 
the correct study type also depends on ethical considerations, disease 
of interest, and the resources available. A well-designed study will 
clearly identify an exposure and an outcome in an objective, 
quantifiable manner to answer a defined hypothesis. After thorough data 
analysis and discussion of the results, the study will ideally prompt 
further research on the subject. Understanding the various indications 
for different study designs is important not only for devising one’s own
 study but also for critically reviewing the literature. This article 
outlines frequently encountered study designs in clinical research and 
their respective strengths and drawbacks.
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